Idiopathic REM sleep behaviour disorder and neurodegeneration-An update,” Nat. How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder,” Brainġ35, 1860– 1870 (2012). Clinical, morphological and neurochemical correlations,” J. (09)70293-5, Google Scholar Crossrefīrain dopamine and the syndromes of Parkinson and Huntington. Initial clinical manifestations of Parkinson's disease: Features and pathophysiological mechanisms,” Lancet Neurol.Ĩ(12), 1128– 1139 (2009). Parkinson's disease: Clinical features and diagnosis,” J. Neurologic Diseases in the Elderly Research Group,” Neurology Prevalence of Parkinson's disease in Europe: A collaborative study of population-based cohorts. It was anticipated that the CPP measures might serve as a promising digital biomarker in assessing the dysphonia from the early stages of PD. The quality of the CPP and CPPS measures was influenced substantially by the addition of ambient noise. Significant differences were found between the PD groups and controls in sustained phonation via the CPP ( p < 0.05) and CPPS ( p < 0.01) and the monologue via the CPP ( p < 0.01), although neither the CPP nor CPPS measures were sufficiently sensitive to capture the possible prodromal dysphonia in the iRBD. The sustained vowel phonation, reading of passages, and monologues of 60 early stage untreated PD, 30 advanced-stage Parkinson's disease, 60 iRBD, and 60 healthy control (HC) participants were evaluated. This study aimed to investigate the voice changes via the CPP measures in the idiopathic rapid eye movement sleep behavior disorder (iRBD), a special case of prodromal neurodegeneration, and recently diagnosed and advanced-stage Parkinson's disease (AS-PD) patients using different speaking tasks across noise-free and noisy environments. Although the cepstral peak prominence (CPP) and its variant, the cepstral peak prominence smooth (CPPS), are considered to be robust acoustic measures for the evaluation of dysphonia, whether they are sensitive to capture early voice changes in Parkinson's disease (PD) has not yet been explored.
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